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徐于喬兼任教授

   徐于喬老師

徐于喬博士（Yu-Chiau Shyu, Ph.D.）

  • 職稱：兼任教授
  • 學歷：國立陽明大學遺傳學研究所博士
  • 專長：基因治療、抗老化醫學、癌症免疫學、細胞訊息傳遞
  • 辦公室電話：+886-2-2432-9292 # 3391
  • E-mail：hungyun@mail.ntou.edu.tw
現職
  • 基隆長庚紀念醫院社區醫學研究中心核心實驗室 副主任
  • 國立臺灣海洋大學海洋生物科技學士學位學程 兼任教授 (2025.08.01~)
學術著作

(A) 期刊論文(Refereed papers)

  1. Shyu, Y.C.#, Liao, P.C.*, Huang, T. S.*, Yang, C.J., Lu, M.J., Huang, S.M., Lin, X.Y., Liou, C.C., Kao, Y.H., Lu, C.H., Peng, H.L., Chen, J.R., Cherng, W.J., Yang, N.I., Chen, Y.C., Pan, H.C., Jiang, S.T., Hsu, C.C., Lin, G., Yuan, S.S., Hsu, P.W., Wu, K.J., Lee, T.L.#, and Shen, C.J.#, (2022) Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice. Adv Sci (Weinh) 9(25):e2201409. (SCIE; IF=14.3; Chemistry, Multidisciplinary 19/231=8.23%, Materials Science, Multidisciplinary 29/439=6.61%, Nanoscience & Nanotechnology 12/141=8.51%)
  2. Wei, Y.C., Kung, Y.C., Lin, C., Yeh, C.H., Chen, P.Y., Huang, W.Y., Shyu, Y.C., Lin, C.P.#, and Chen, C.K.#, (2024) Differential neuropsychiatric associations of plasma biomarkers in older adults with major depression and subjective cognitive decline. Transl Psychiatry 14(1):333 (SCIE, IF=5.8; Psychiatry 25/279=8.96%)
  3. Huang, L.Y.*, Lim, A.Y.*, Hsu, C.C., Tsai, Y.F., Fu, T.C., Shyu, Y.C., Peng, S.C., and Wang, J.S.#, (2024) Sustainability of exercise-induced benefits on circulating MicroRNAs and physical fitness in community-dwelling older adults: a randomized controlled trial with follow up. BMC Geriatr 24(1):473 (SCIE; IF=3.4; Geriatrics & Gerontology 32/74=43.2%; Gerontology 12/47=25.53%)
  4. Wei, Y.C.*, Kung, Y.C.*, Lin, C.P., Chen, C.K., Lin, C., Tseng, R.Y., Chen, Y.L., Huang, W.Y., Chen, P.Y., Chong, S.T., Shyu, Y.C., Chang, W.C., and Yeh, C.H., (2024) White matter alterations and their associations with biomarkers and behavior in subjective cognitive decline individuals: a fixel-based analysis. Behav Brain Funct 20(1):12 (SCIE; IF=4.7; Behavioral Sciences 6/55=10.9%; Neurosciences 63/310=20.3%)
  5. Wang, J.P.*, Hung, C.H.*, Liou, Y.H., Liu, C.C., Yeh, K.H., Wang, K.Y., Lai, Z.S., Chatterjee, B., Hsu, T.C., Lee, T.L., Shyu, Y.C. #, Hsiao, P.W., Chen, L.Y., Chuang, T.J., Yu, C.A., Liao, N.S., and Shen, C.J.#, (2024) Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells. eLife 12:RP88275 (SCIE; IF=6.4; Biology 8/109=7.34%)
  6. Wei, Y.C., Chen, C.K., Lin, C., Shyu, Y.C., and Chen, P.Y.#, (2024) Life After Traumatic Brain Injury: Effects on the Lifestyle and Quality of Life of Community-Dwelling Patients. Neurotrauma Rep 5(1):159-171 (SCIE; IF=1.8; Clinical Neurology 190/280=67.86%, Neurosciences 242/310=78.06%)
  7. Shyu, Y.C.#, Huang, T.S., Chiu, H.S., Sumazin, P., Lin, X.Y., Liao, P.C., Liou, C.C., Hsu, F.C., Lin, J.S., Hsu, C.C., Hsu, P.H., Sun, C.C., and Chen, C.T. #, (2024) Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model. Int J Mol Sci 25(4) (SCIE; IF=4.9; Biochemistry & Molecular Biology 66/313=21.09% Chemistry, Multidisciplinary 68/231=29.44%)
  8. Lin, C., Yeh, F.C., Glynn, N.W., Gmelin, T., Wei, Y.C., Chen, Y.L., Huang, C.M., Shyu, Y.C., and Chen, C.K.#, (2024) Associations of depression and perceived physical fatigability with white matter integrity in older adults. Psychiatry Res Neuroimaging 340:111793. (SCIE; IF=2.1; Clinical Neurology 168/280=58.21%; Neuroimaging 10/15=66.67%; Psychiatry 148/279=53.05% )
  9. Wei, Y.C.#, Hsu, C.H.#, Huang, W.Y., Lin, C., Chen, C.K., Chen, Y.L., Chen, P.Y., Shyu, Y.C., and Lin, C.P. , (2023) Vascular Risk Factors and Astrocytic Marker for the Glymphatic System Activity. Radiol Med 128(9):1148-1161. (SCIE; IF=9.7; Radiology, Nuclear Medicine & Medical Imaging 5/204=2.45%)
  10. Shen, L., Chen, Y.L., Huang, C.C., Shyu, Y.C., Seftor, R.E.B., Seftor, E.A., Hendrix, M.J.C., Chien, D.S., and Chu, Y.W.#, (2023) CVM-1118 (Foslinanib), A 2-Phenyl-4-Quinolone Derivative, Promotes Apoptosis and Inhibits Vasculogenic Mimicry via Targeting TRAP1. Pathol Oncol Res 29:1611038. (SCIE; IF=2.3; Oncology 202/322=62.73%, Pathology 42/88=47.73%)
  11. Hsu, C.C. #, Wang, J.S., Shyu, Y.C., Fu, T.C., Juan, Y.H., Yuan, S.S., Wang, C.H., Yeh, C.H., Liao, P.C., Wu, H.Y., and Hsu, P.H. #, (2023) Hypermethylation of ACADVL is Involved in the High-Intensity Interval Training-Associated Reduction of Cardiac Fibrosis in Heart Failure Patients. J Transl Med 21(1):187. (SCIE; IF=6.1; Medicine, Research & Experimental 29/189=15.34%)
  12. Wu, I.W., Tsai, T.H., Lo, C.J., Chou, Y.J., Yeh, C.H., Chan, Y.H., Chen, J.H., Hsu, P.W., Pan, H.C., Hsu, H.J., Chen, C.Y., Lee, C.C., Shyu, Y.C., Lin, C.L., Cheng, M.L., Lai, C.C. #, Sytwu, H.K.#, and Tsai, T.F. #, (2022) Discovering a Trans-Omics Biomarker Signature that Predisposes High Risk Diabetic Patients to Diabetic Kidney Disease. NPJ Digit Med 5(1):166. (SCIE; IF=12.4; Health Care Sciences & Services 2/174=1.15%, Medical Informatics 2/44=4.55%)
  13. Hsu, P.W., Liao, P.C., Kao, Y.H., Lin, X.Y., Chien, R.N., Yeh, C.T., Lai, C.C., Shyu, Y.C.#, and Lin, C. L.#, (2022) The Mutation Hotspots at UGT1A Locus May Be Associated with Gilbert's Syndrome Affecting the Taiwanese Population. Int J Mol Sci 23(20):12709. (SCIE; IF=4.9; Biochemistry & Molecular Biology 66/313=21.09% Chemistry, Multidisciplinary 68/231=29.44%)
  14. Wang, L.J., Lin, C.L., Chen, Y.C., Lin, C., Shyu, Y.C., and Chen, C.K. #, (2022) Sex Differences in the Relationship between Excessive Alcohol Consumption and Metabolic Abnormalities: A Community-Based Study in Taiwan. Nutrients 14(14):2957. (SCIE; IF=4.8; Nutrition & Dietetics 18/114=15.79%)
  15. Lee, K.Y.*, Seah, C., Li, C., Chen, Y.F., Chen, C.Y., Wu, C.I., Liao, P.C., Shyu, Y.C., Olafson, H.R., McKee, K.K., Wang, E.T., Yeh, C.H., and Wang, C.H.*, (2022) Mice Lacking MBNL1 and MBNL2 Exhibit Sudden Cardiac Death and Molecular Signatures Recapitulating Myotonic Dystrophy. Hum Mol Genet 31(18), 3144-3160. (SCIE; IF=3.1; Biochemistry & Molecular Biology 168/313 =53.67%, Genetics & Heredity 73/191=38.22%)
  16. Wei, Y.C., Chen, C.K., Lin, C., Chen, P.Y., Hsu, P.C., Lin, C.P., Shyu, Y.C., and Huang, W.Y.#, (2022) Normative Data of Mini-Mental State Examination, Montreal Cognitive Assessment, and Alzheimer's Disease Assessment Scale-Cognitive Subscale of Community-Dwelling Older Adults in Taiwan. Dement Geriatr Cogn Disord 51(4):365-376. (SCIE; IF=2.2; Clinical Neurology 156/280=55.71%, Geriatrics & Gerontology 48/74=64.86%, Psychiatry 141/279=50.54%)
  17. Wei, Y.C., Kung, Y.C., Huang, W.Y., Lin, C., Chen, Y.L., Chen, C.K., Shyu, Y.C., and Lin, C.P.#, (2022) Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline. Front Aging Neurosci 14:817137. (SCIE; IF=4.1; Geriatrics & Gerontology 22/74=29.73%, Neurosciences 81/310=26.13%)
  18. Lin, C.L.*, Lin, Y.L.*, Liang, K.H., Chen, L.W., Chien, C.H., Hu, C.C., Huang, T.S., Shyu, Y.C., Yeh, C.T.#, and Chien, R.N., (2022). Prognosis Comparison between Chronic Hepatitis B Patients Receiving a Finite Course of Tenofovir and Entecavir Treatment: A Nationwide Cohort Study in Taiwan. Clin Ther 44(3):403-417 e406. (SCIE; IF=3.2; Pharmacology & Pharmacy 124/354=35.03%)
  19. Huang, T.S., Wu, I.W., Lin, C.L., Shyu, Y.C., Chen, Y.C., and Chien, R.N.#, (2022). Prognosis of Chronic Kidney Disease in Patients with Non-Alcoholic Fatty Liver Disease: a Northeastern Taiwan Community Medicine Research Cohort. Biomed J 46(2):100532 (SCIE; IF=4.1; Biochemistry & Molecular Biology 97/313 =30.99%, Medicine, Research & Experimental 62/279=50.54%)
  20. Fu, T.S., Huang, T.S., Sun, C.C., Shyu, Y.C., Chen, F.P.#, (2022). Impact of Bisphosphonates and Comorbidities on Initial Hip Fracture Prognosis. Bone 154:116239. (SCIE; IF=3.5; Endocrinology & Metabolism 68/186=36.56%)
  21. Lin, C.L., Chien, R.N., Chen, L.W., Huang, T.S., Shyu, Y.C., Yeh, C.T.#, Liang, K.H.#, (2021). The Aldehyde Dehydrogenase ALDH2*2 Allele, Associated with Alcohol Drinking Behavior, Dates Back to Prehistoric Times. Biomolecules 11(9):1376. (SCIE; IF=4.8; Biochemistry & Molecular Biology 67/313=21.41%)
  22. Yang, N.I., Yeh, C.H., Tsai, T.H., Chou, Y.J., Hsu, P.W., Li, C.H., Chan, Y.H., Kuo, L.T., Mao, C.T., Shyu, Y.C., Hung, M.J., Lai, C.C.#, Sytwu, H.K.#, Tsai, T.F.#, (2021). Artificial Intelligence-Assisted Identification of Genetic Factors Predisposing High-Risk Individuals to Asymptomatic Heart Failure. Cells 10(9):2430. (SCIE; IF=5.1; Cell Biology 63/205=30.73%)
  23. Wei, Y.C., Hsu, C.H., Huang, W.Y., Chen, Y.L., Lin, C., Chen, C.K., Lin, C., Shyu, Y.C., Lin, C.P.#, (2021). White Matter Integrity Underlies the Physical-Cognitive Correlations in Subjective Cognitive Decline. Front Aging Neurosci 13:700764. (SCIE; IF=4.1; Geriatrics & Gerontology 22/74=29.73%, Neurosciences 81/310=26.13%)
  24. Hung, C.H.*, Lee, T.L.*, Huang, A.Y.*, Yang, K.C.*, Shyu, Y.C., Wen, S.C., Lu, M.J., Yuan, S.#, Shen, C.J.#, (2021). A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis. Int J Mol Sci 22(15):8024. (SCIE; IF=4.9; Biochemistry & Molecular Biology 66/313=21.09% Chemistry, Multidisciplinary 68/231=29.44%)
  25. Wu, L.L.*, Huang, T.S.*, Shyu, Y.C., Wang, C.L., Wang, H.Y.#, Chen, P.J.#, (2021). Gut Microbiota in the Innate Immunity Against Hepatitis B Virus - Implication in Age-Dependent HBV Clearance. Curr Opin Virol 49:194-202. (SCIE; IF=5.7; Virology 5/41=12.20)
  26. Chen, L.W., Huang, M.S., Shyu, Y.C., Chien, R.N.#, (2021). Gamma-Glutamyl Transpeptidase Elevation is Associated with Metabolic Syndrome, Hepatic Steatosis, and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: A Community-Based Cross-Sectional Study. Kaohsiung J Med Sci 37(9):819-827. (SCIE; IF=2.7; Medicine, Research & Experimental 95/189 =50.26%)
  27. Lin, C., Glynn, N.W., Gmelin, T., Wei, Y.C., Chen, Y.L., Huang, C.M., Shyu, Y.C., Chen, C.K.#, (2021). Validation of the Traditional Chinese Version of the Pittsburgh Fatigability Scale for Older Adults. Clin Gerontol 45(3):606-618. (SCIE; IF=2.6; Psychiatry 115/279 =41.22%)
  28. Hung, N., Kang, E.Y., Lee, T.W., Chen, T.H., Shyu, Y.C., Sun, C.C.#, (2021). The Risks of Corneal Surface Damage in Aqueous-Deficient Dry Eye Disease: A 17-Year Population-Based Study in Taiwan. Am J Ophthalmol 227:231-239. (SCIE; IF= 4.1; Ophthalmology 12/95 =12.63%)
  29. Wei, Y.C., Huang, L.Y., Lin, C., Shyu, Y.C., Chen, C.K.#, (2021). Taiwanese Depression Questionnaire and AD8 Questionnaire for Screening Late-Life Depression in Communities. Neuropsychiatr Dis Treat 17:747-755. (SCIE; IF=2.5; Psychiatry 120/279 =43.01%, Clinical Neurology 130/280=46.43%)
  30. Hung, C.H., Wang, K.Y., Liou, Y.H., Wang, J.P., Huang, A.Y., Lee, T.L., Jiang, S.T., Liao, N.S., Shyu, Y.C.#, Shen, C.J.#, (2020). Negative Regulation of the Differentiation of Flk2(-) CD34(-) LSK Hematopoietic Stem Cells by EKLF/KLF1. Int J Mol Sci 21(22):8448. (SCIE; IF=5.6; Biochemistry & Molecular Biology 66/285=23.16% Chemistry, Multidisciplinary 52/178=29.21%)
  31. Peng, P.H., Tsai, M.Y., Lee, S.Y., Liao, P.C., Shyu, Y.C.#, Wang, L.J.#, (2020). Attention-Deficit/Hyperactivity Disorder, Its Pharmacotherapy, and Adrenal Gland Dysfunction: A Nationwide Population-Based Study in Taiwan. Int J Environ Res Public Health 17(10):3709. (SCIE; IF=4.614; Public, Environmental & Occupational Health 71/210=33.81%, Environmental Sciences 100/279=35.84%)
  32. Soong, R.S., Anchoori, R.K., Roden, R.B.S., Cho, R.L., Chen, Y.C., Tseng, S.C., Huang, Y.L., Liao, P.C., Shyu, Y.C.#, (2020). Bis-Benzylidine Piperidone RA190 Treatment of Hepatocellular Carcinoma via Binding RPN13 and Inhibiting NF-kappaB Signaling. BMC Cancer 20(1):386. (SCIE; IF=3.4; Oncology 110/322=34.16%)
  33. Yeh, J.Y., Shyu, Y.C., Lee, S.Y., Yuan, S.S., Yang, C.J., Yang, K.C., Lee, T.L., Sun, C.C., Wang, L.J.#, (2020). Comorbidity of Narcolepsy and Psychotic Disorders: A Nationwide Population-Based Study in Taiwan. Front Psychiatry 11:205. (SCIE; IF=3.2; Psychiatry 88/279=31.54%)
  34. Wang, L.J., Lee, S.Y., and Shyu, Y.C.#, (2019) Dr Wang and Colleagues Reply. J Clin Psychiatry 80(2):19lr12732a. (SCIE; IF=4.5; Psychiatry 45/279=16.13%)
  35. Huang, K.S., Shyu, Y.C., Lin, C.L., Wang, F.B.#, (2019). Mathematical Analysis of an HBV Model with Antibody and Spatial Heterogeneity. Math Biosci Eng 17(2):1820-1837. (SCIE; IF=2.6; Mathematical & Computational Biology 24/55=43.64%)
  36. Wei, Y.C.#, Chen, K.F., Wu, C.L., Lee, T.W., Liu, C.H., Shyu, Y.C., Lin, C.P.#, (2019). Stroke Rate Increases Around the Time of Cancer Diagnosis. Front Neurol 10:579. (SCIE; IF=2.7; Clinical Neurology 112/280=40.00%, Neurosciences 158/310=50.97%)
  37. Machado, M.O., Stergiopoulos, V., Maes, M., Kurdyak, P.A., Lin, P.Y., Wang, L.J., Shyu, Y.C., Firth, J., Koyanagi, A., Solmi, M., Alavi, A., Piguet, V., Carvalho, A.F.#, (2019). Depression and Anxiety in Adults with Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis. JAMA Dermatol 155(8):939-945. (SCIE; IF=11.5; Dermatology 2/94=2.13%)
  38. Hsu, C.C., Fu, T.C., Yuan, S.S.*#, Wang, C.H., Liu, M.H., Shyu, Y.C., Cherng, W.J., Wang, J.S.*#, (2019). High-Intensity Interval Training is Associated with Improved Long-Term Survival in Heart Failure Patients. J Clin Med 8(3):409. (SCIE; IF=3.0; Medicine, General & Internal 59/329=17.93%)
  39. Shyu, Y.C., Huang, T.S., Chien, C.H., Yeh, C.T., Lin, C.L.#, Chien, R.N.#, (2019). Diabetes Poses a Higher Risk of Hepatocellular Carcinoma and Mortality in Patients with Chronic Hepatitis B: A Population-Based Cohort Study. J Viral Hepat 26(6):718-726. (SCIE; IF=2.5; Gastroenterology & Hepatology 72/143=50.35%; Infectious Diseases 74/132=56.06%; Virology 25/41=60.98%)
  40. Wang, L.J., Lee, S.Y., Chou, W.J., Lee, M.J., Tsai, C.S., Lee, T.L., Yang, C.J., Yang, K.C., Chen, C.K., Shyu, Y.C.#, (2019). Testicular Function after Long-Term Methylphenidate Treatment in Boys with Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol 29(6):433-438. (SCIE; IF=1.5; Pediatrics 86/186=46.24%; Pharmacology & Pharmacy 265/354=74.86%; Psychiatry 192/279=68.82%)
專利
  1. 延長壽命與抑制腫瘤發生的動物模型
  2. 藉移植增加壽命及/或治療細胞增殖疾病之方法
  3. 基因編輯幹細胞在急性腎損傷中具有保護作用
  4. 基因編輯幹細胞用於治療纖維化
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